Vaccine used for treating bladder cancer and diabetes is safe!

1.25 million people In USA suffer from type 1 (ONE) diabetes. The body of those people with type 1 diabetes does not produce insulin. A vaccine for tuberculosis used over hundred years ago (bacillus Calmette-Guerin ) has shown promise in reversing this disease. This vaccine is now commonly known and used for treating bladder cancer. What is most important, doctors consider to be safe.

There was an announcement of the American Diabetes Association that the FDA will in fact test the vaccine on 150 people who are in an advanced stage of type 1 diabetes.

It is like that due to the immune system destroying the cells that in fact create insulin. T cells are produced, and these cells actually create problems in the pancreatic islets, where insulin is produced.

The vaccine works by eliminating these T cells.

Vaccine used for treating bladder cancer and diabetes is safe

 

Patients with diabetes injected with the vaccine saw an increase in the levels of a substance called tumor necrosis factor (TNF). The increased level of TNF in the system actually destroys those T cells that are hindering the production of insulin.

In a previous trial,  patients had tuberculosis vaccine injection twice within a frame of four-weeks. The results showed that the dangerous T cells actually disappeared, and some people even began to secrete little insulin on their own.

Dr. Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory in Boston, is very excited about the results the BCG vaccine has been showing.

“In the phase I (preliminary) trial we demonstrated a statistically significant response to BCG. But our goal in (this trial) is actually to create a lasting therapeutic response. We will be working again with people who have had type 1 diabetes for many years. This is not a prevention trial; instead, we are trying to create a regimen that will treat even advanced disease” explained Dr. Denise.

There’s a new trial coming which will use the same format as the previous one, on people at the age between 18 and 60. There will be vaccine injection for the subjects twice in a period of four weeks. The next step will be once a year for a 4-year time span.

The Diabetes Care journal has published the results of a past study which analyzed the effects of Bacillus Calmette-Guerin (BCG) on kids with diabetes at the age between 5 and 18. The results showed that the BCG vaccine doesn’t keep the beta-cell function or raise the remission rate in kids.

 

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